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Patient Instructions


Each ENDOMETRIN® insert supplies 100 mg of natural progesterone and comes with its own single-use disposable applicator for sterile insertion into the vagina, 2 or 3 times a day as your doctor prescribes.
Your doctor will have you begin using ENDOMETRIN® starting the day after egg retrieval, and upon a positive pregnancy test, continuing for up to 10 weeks total duration.
Unlike some progesterone products that may require you to lie down when inserting them and to remain lying down for a period of time afterwards, ENDOMETRIN® can be inserted while you are standing, sitting, or lying on your back with your knees bent.

For more information you can visit Ferring Pharmaceutical


By Mouth~
For hormone replacement therapy: 200 mg micronized progesterone (Prometrium) per day is typically taken for 12 days of a 25-day cycle with 0.625 mg conjugated estrogens.

Applied to the Skin~
For hot flashes and other symptoms of menopause: 20 mg progesterone cream (equivalent to 1/4 teaspoon Progest cream) is typically applied daily to rotating places on the body including upper arms, thighs, or breasts.

Inside the Vagina~
For breast pain associated with noncancerous breast disease: a typical dose of 4 grams of vaginal cream containing 2.5% natural progesterone is placed inside the vagina from the 19th to the 25th day of a 28-day cycle.
For restoring menstrual periods in women who have not reached menopause: one applicator (90 mg) of progesterone gel (Crinone 4% or 8%) is typically placed inside the vagina every other day for 6 days per month.

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For hormone replacement therapy, one applicator (90 mg) of progesterone gel (Crinone 4% or 8%) is typically placed inside the vagina on days 17, 19, 21, 23, 25, and 27 of a 28-day cycle with 0.625 mg conjugated equine estrogens.
For reducing vaginal bleeding and reversing the thickening of the lining of the uterus in premenopausal women with noncancerous endometrial hyperplasia: a dose of 100 mg progesterone cream placed inside the vagina daily from day 10 to day 25 of a 28-day cycle has been used.


NOVAREL® is one of the first hCGs approved for use in OI. NOVAREL® is injected intramuscularly (into the muscle) according to the directions provided by your doctor.
NOVAREL® is used to stimulate egg release (ovulation) in women who are not ovulating and in whom ovarian failure is not the cause of infertility, Before using NOVAREL®, patients will typically receive treatment with gonadotropins, such as BRAVELLE® (urofollitropin for injection, purified), MENOPUR® (menotropins for injection, USP), or REPRONEX® (menotropins for injection, USP).

For more information you can visit Ferring Pharmaceutical


Use for Endometriosis~
LUPRON DEPOT® (leuprolide acetate for depot suspension) 3.75 mg and –3 Month 11.25 mg is used for the management of endometriosis, including pain relief and reduction of endometriotic lesions. LUPRON DEPOT® with daily norethindrone acetate 5 mg is also indicated for initial management of endometriosis and for management of recurrence of symptoms. The recommended initial treatment is no more than 6 months. Repeat treatment for endometriosis should be limited to 6 months.

Use for Fibroids~
LUPRON DEPOT® (leuprolide acetate for depot suspension) 3.75 mg and –3 Month 11.25 mg with iron therapy are used before fibroid surgery to improve anemia due to vaginal bleeding from fibroids. Your doctor may consider a one-month trial of iron alone as some patients’ anemia will improve with iron alone. It is recommended that LUPRON DEPOT® not be used for more than 3 months in patients with fibroids. Experience with LUPRON DEPOT® in females has been limited to women 18 years of age and older.

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Ovidrel® PreFilled Syringe contains recombinant hCG, an injectable hormone. This is the hormone that causes eggs to finish maturing and be released. Ovidrel® PreFilled Syringe is used in infertility treatment cycles following treatment with products containing human follicle stimulating hormone, such as Gonal-f® (follitropin alfa for injection).
The hormone in the Ovidrel® PreFilled Syringe is manufactured to meet standards for quality and purity.
However, following our commitment to the area of reproductive health, Ovidrel® PreFilled Syringe is the only hCG available for subcutaneous (just under the skin) injection in the United States.

Ovidrel® Indication
Ovidrel® PreFilled Syringe is indicated for the induction of final follicular maturation and early luteinization in infertile women who have undergone pituitary desensitization and who have been appropriately pretreated with follicle stimulating hormones as part of an Assisted Reproductive Technology (ART) program such as in vitro fertilization and embryo transfer. Ovidrel® PreFilled Syringe is also indicated for the induction of ovulation (OI) and pregnancy in anovulatory infertile patients in whom the cause of infertility is functional and not due to primary ovarian failure.


Your baby story could begin with BRAVELLE®, a highly purified preparation of human FSH.
BRAVELLE® is used to stimulate egg maturation, and for multiple follicular development in women who are able to produce and release eggs (ovulate). BRAVELLE® is also used to increase the potential for success in ART.
You can administer BRAVELLE® by subcutaneous (under the skin) injection, with or without a partner—a process made easier with our patented Q•Cap® vial adapter.

For more information you can visit Ferring Pharmaceutical

SQ Injection

The video below will demonstrate the proper way to give a subcutaneous injection.  Please consult with the nurse or doctor if you are unable to give injections on your own or have any further questions.


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